Cellular and Molecular Immunology

The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The 9th Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers...

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The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The 9th Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area.

Abul Abbas

Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Affiliations and Expertise

Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Andrew Lichtman

Affiliations and Expertise

Associate Professor of Pat...

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Abul Abbas

Abul K. Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Affiliations and Expertise

Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California

Andrew Lichtman

Affiliations and Expertise

Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

Shiv Pillai

Affiliations and Expertise

Massachusetts General Hospital Cancer Center, Boston, MA, USA

Cover image
Title Page
Table of Contents
Copyright
Dedication
Preface
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Cover image
Title Page
Table of Contents
Copyright
Dedication
Preface
Online Resources for Instructors and Students
Resources for Instructors
Resources for Students
1 Properties and Overview of Immune Responses
Innate and Adaptive Immunity
Innate Immunity: the Early Defense
Adaptive Immunity
Summary
Selected Readings
2 Cells and Tissues of the Immune System
Cells of the Immune System
Anatomy and Functions of Lymphoid Tissues
Summary
Selected Readings
3 Leukocyte Circulation and Migration into Tissues
Overview of Leukocyte Migration
Adhesion Molecules on Leukocytes and Endothelial Cells Involved in Leukocyte Recruitment
Chemokines and Chemokine Receptors
Leukocyte-Endothelial Interactions and Leukocyte Recruitment Into Tissues
Migration of Neutrophils and Monocytes to Sites of Infection or Tissue Injury
Migration and Recirculation of T Lymphocytes
Migration of B Lymphocytes
Summary
Selected Readings
4 Innate Immunity
Overview of Innate Immunity
Recognition of Microbes and Damaged Self by the Innate Immune System
Cell-Associated Pattern Recognition Receptors and Sensors of Innate Immunity
Cellular Components of the Innate Immune System
Soluble Effector Molecules of Innate Immunity
The Inflammatory Response
The Antiviral Response
Stimulation of Adaptive Immunity
Mechanisms That Limit Innate Immune Responses
Summary
Suggested Readings
5 Antibodies and Antigens
Antibody Structure
Synthesis, Assembly, and Expression of Immunoglobulin Molecules
Antibody Binding of Antigens
Structure-Function Relationships in Antibody Molecules
Summary
Suggested Readings
6 Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules
Properties of Antigens Recognized by T Lymphocytes
Antigen Capture and the Functions of Antigen-Presenting Cells
The Major Histocompatibility Complex
Processing of Protein Antigens
Presentation of Nonprotein Antigens to T Cells
Summary
Suggested Readings
7 Immune Receptors and Signal Transduction
Overview of Signal Transduction
The Immune Receptor Family
The T Cell Receptor Complex and T Cell Signaling
The B Lymphocyte Antigen Receptor Complex
The Attenuation of Immune Receptor Signaling
Cytokine Receptors and Signaling
Summary
Suggested Readings
8 Lymphocyte Development and Antigen Receptor Gene Rearrangement
Overview of Lymphocyte Development
Rearrangement of Antigen Receptor Genes in B and T Lymphocytes
B Lymphocyte Development
T Lymphocyte Development
Summary
Suggested Readings
9 Activation of T Lymphocytes
Overview of T Lymphocyte Activation
Signals for T Lymphocyte Activation
Functional Responses of T Lymphocytes
Decline of T Cell Responses
Summary
Selected Readings
10 Differentiation and Functions of CD4+ Effector T Cells
Overview of CD4+ T Cell-Mediated Immune Responses
Subsets of CD4+ Effector T Cells
The Th1 Subset
The Th2 Subset
The Th17 Subset
Functions of Other T Cell Subsets
Summary
Suggested Readings
11 Differentiation and Functions of CD8+ Effector T Cells
Differentiation of CD8+ T Cells Into Cytotoxic T Lymphocytes
Effector Functions of CD8+ Cytotoxic T Lymphocytes
Roles of CD8+ CTLs in Host Defense
Summary
Selected Readings
12 B Cell Activation and Antibody Production
Overview of Humoral Immune Responses
Antigen Recognition and Antigen-Induced B Cell Activation
Helper T Cell-Dependent Antibody Responses to Protein Antigens
Antibody Responses to T-Independent Antigens
Antibody Feedback: Regulation of Humoral Immune Responses by Fc Receptors
Summary
Selected Readings
13 Effector Mechanisms of Humoral Immunity
Overview of Humoral Immunity
Neutralization of Microbes and Microbial Toxins
Antibody-Mediated Opsonization and Phagocytosis
The Complement System
Neonatal Immunity
Summary
Selected Readings
14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
General Features of Immunity at Epithelial Barriers
Immunity in the Gastrointestinal System
Immunity in Other Mucosal Tissues
The Cutaneous Immune System
Immune-Privileged Tissues
Summary
Selected Readings
15 Immunologic Tolerance and Autoimmunity
Overview of Immunologic Tolerance
T Lymphocyte Tolerance
B Lymphocyte Tolerance
Tolerance to Commensal Microbes and Other Foreign Antigens
Mechanisms of Autoimmunity
Summary
Selected Readings
16 Immunity to Microbes
Overview of Immune Responses to Microbes
Immunity to Extracellular Bacteria
Immunity to Intracellular Bacteria
Immunity to Fungi
Immunity to Viruses
Immunity to Parasites
Strategies for Vaccine Development
Summary
Selected Readings
17 Transplantation Immunology
General Principles of Transplantation Immunology
Adaptive Immune Responses to Allografts
Patterns and Mechanisms of Allograft Rejection
Prevention and Treatment of Allograft Rejection
Xenogeneic Transplantation
Blood Transfusion and the ABO and Rh Blood Group Antigens
Hematopoietic Stem Cell (HSC) Transplantation
Summary
Selected Readings
18 Immunity to Tumors
Overview of Tumor Immunity
Tumor Antigens
Immune Responses to Tumors
Evasion of Immune Responses by Tumors
Immunotherapy for Tumors
Summary
Selected Readings
19 Hypersensitivity Disorders
Causes of Hypersensitivity Diseases
Mechanisms and Classification of Hypersensitivity Reactions
Diseases Caused by Antibodies
Diseases Caused by T Lymphocytes
Therapeutic Approaches for Immunologic Diseases
Selected Immunologic Diseases: Pathogenesis and Therapeutic Strategies
Summary
Selected Readings
20 Allergy
Overview of IgE-Dependent Allergic Reactions
Production of IgE
Cells Involved in Allergic Reactions
IgE- and Mast Cell–Dependent Reactions
Genetic Susceptibility to Allergic Disease
Allergic Diseases in Humans: Pathogenesis and Therapy
The Protective Roles of IgE- and Mast Cell–Mediated Immune Reactions
Summary
Selected Readings
21 Congenital and Acquired Immunodeficiencies
Overview of Immunodeficiency Diseases
Primary (Congenital) Immunodeficiencies
Secondary (Acquired) Immunodeficiencies
Human Immunodeficiency Virus and the Acquired Immunodeficiency Syndrome
Summary
Selected Readings
Glossary
Appendices
Appendix I Cytokines
Appendix II Principal Features of Selected CD Molecules
Appendix III Laboratory Techniques Commonly Used in Immunology
Laboratory Methods Using Antibodies
Transgenic Mice and Gene Targeting
Methods for Studying T Lymphocyte Responses
Methods for Studying B Lymphocyte Responses
Clinical Diagnostic Applications of Immunologic Assays
Index
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