hedgehog对《The Gene》的笔记(24)

hedgehog
hedgehog (靡不有初,鲜克有终)

读过 The Gene

The Gene
  • 书名: The Gene
  • 作者: Siddhartha Mukherjee
  • 副标题: An Intimate History
  • 页数: 608
  • 出版社: Scribner
  • 出版年: 2016-5-17
  • 第11页
    it is impossible to understand organismal and cellular biology or evolution - or human pathology, behavior, temperament, illness, race, and identity or fate - without first reckoning with the concept of the gene
    2017-06-09 15:42:05 回应
  • 第30页
    A scientist could understand the present and the future by examining the "battered relics" of the past.
    2017-06-09 15:43:02 回应
  • 第127页
    The Nazis -- believing in absolute genetic immutability ("a Jew is a Jew") -- had resorted to eugenics to change the structure of their population. The Soviets -- believing in absolute genetic reprogrammability ("anyone is everyone") -- could eradicate all distinctions and thus achieve a radical collective good.
    2017-06-21 15:20:31 1人喜欢 回应
  • 第133页
    Like musicians, like mathematicians - like elite athletes - scientists peak early and dwindle fast. It isn't creativity that fades, but stamina: science is an endurance sport. To produce that single illuminating experiment, a thousand nonilluminating experiments have to be sent into the trash; it is battle between nature and nerve.
    2017-06-26 15:40:36 回应
  • 第134页
    Organisms exist not because of reactions that are possible, but because of reactions that are barely possible. Too much reactivity and we would spontaneously combust. Too little, and we would turn cold and die.
    2017-06-26 15:41:53 回应
  • 第234页
    There is an illuminated moment in the development of a child when she grasp the recursiveness of language: just as thought can be used to generate words, she realizes, words can be used to generate thoughts. Recomninant DNA had made the language of genetics recursive.
    2017-07-07 10:19:55 回应
  • 第249页
    It is tempting to write the history of technology through products: the wheel; the microscope; the airplane; the Internet. But it is more illuminating to write the history of technology through transition: linear motion to circular motion; visual space to subvisual space; motion on land to motion in air; physical connectivity to virtual connectivity.
    2017-07-07 10:21:56 回应
  • 第276页
    Genetic illness and genetic wellness were not discrete neighboring countries; rather, wellness and illness were continuous kingdoms, bounded by thin, often transparent, borders ...... What if "disease-causing" gene variants were also genius enabling?
    2017-07-07 10:24:11 回应
  • 第281页
    The polymorphisms would act like an internal GPS system for the genome; a gene's location could be pinpionted by its association, or linkagem to one such variant.......The real key to human gene mapping, Botstein had realized, was not finding the gene, but finding the human. If a large-enough family bearing a genetic trait - any trait - could be found, and if that trait could be correlated with any of the variant markers spread across the genome, then gene mapping would become a trivial task.
    2017-07-10 15:08:13 回应
  • 第316页
    Of the 289 human genes known to be involved with a disease, 177 genes - more than 60 percent - had a related counterpart in the fly. There were no gene for sickle-cell anemia or hemophilia - flies do not have red blood cells or forms clots - but genes involved in colon cancer, breast cancer, Tay-Sachs disease, muscular dystrophy, cystic fibrosis, Alzheimer's disease, Parkinson's disease, and diabetes, or close counterparts of those genes, were present.
    2017-07-10 15:12:05 回应
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