出版社: The Johns Hopkins University Press
副标题: A Concise Guide
出版年: 20040702
页数: 232
定价: $30.95
装帧: Paperback
ISBN: 9780801880094
内容简介 · · · · · ·
Review
"John Gillespie has done the nearimpossible, condensing the essence of population genetics into a very short book. The result is a little gem. The derivations are simple and clear, and often strikingly original. The minor gaps in the first edition are filled by this equally concise second edition. Population genetics is a complicated subject; only a person of Gillespie'...
Review
"John Gillespie has done the nearimpossible, condensing the essence of population genetics into a very short book. The result is a little gem. The derivations are simple and clear, and often strikingly original. The minor gaps in the first edition are filled by this equally concise second edition. Population genetics is a complicated subject; only a person of Gillespie's depth of knowledge and insight could simplify without distorting."
 James F. Crow, author of Genetics Notes
"The book is coherently and logically structured and covers all the most important and incontrovertible aspects of population genetics... I recommend this as a good introductory book that can be used in both undergraduate and graduate courses."
 Heredity
"A welldeveloped, thoughtful, and classic book that has been tested and improved through many years in the classroom... A 'must' for anyone interested in plant or animal genetics."
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AEIOU (幸福的奥地利，结婚去吧。)
Chapter 1  The HardyWeinberg Law I feel strongly that a student who understands well the core of population genetics is much better equipped to understand evolution than is one who understands less well each of a greater number of topics. It differs from much of biology in that its important insights are theoretical rather than observational or experimental. The objects of study are primarily...20110402 12:58
Chapter 1  The HardyWeinberg LawI feel strongly that a student who understands well the core of population genetics is much better equipped to understand evolution than is one who understands less well each of a greater number of topics.
It differs from much of biology in that its important insights are theoretical rather than observational or experimental.
The objects of study are primarily the frequencies and fitnesses of genotypes in natural populations. Evolution is the change in the frequencies of genotypes through time, perhaps due to their differences in fitness. While genotype frequencies are easily measured, their change is not. The time scale of change of most naturally occurring genetic variants is very long, probably on the order of tens of thousands to millions of years. Changes this slow are impossible to observe directly. Fitness differences between genotypes, which may be responsible for some of the frequency changes, are so extraordinarily small, probably less than 0.01 percent, that they too are impossible to measure directly. Although we can observe the state of a population, there really is no way to explore directly the evolution of a population.
Years ago, Ernst Mayr mocked this approach as “bean bag genetics”. In so doing, he echoed a view held by many of the pioneers of our field that natural selection acts on highly interactive coadapted genomes whose evolution cannot be understood by considering the evolution of a few loci in isolation from all others. Although genomes are certainly coadapted, there is precious little evidence that there are strong interactions between most polymorphic alleles in natural populations. The modern view, spurred on by the rush of DNA sequence data, is that we can profitably study loci in isolation.
The HardyWeinberg law describes the equilibrium state of a single locus in a randomly mating diploid population that is free of other evolutionary forces, such as mutation, migration, and genetic drift.
The autosomal loci of hermaphrodites reach their HardyWeinberg equilibrium in a single generation of random mating, no matter how far the initial genotype frequencies are from their equilibrium values.
Chapter 2  Genetic DriftThe frequencies of the alleles do not change M a result of random mating. Random mating can change genotype frequencies, not allele frequencies. Consequently, the HardyWeinberg genotype frequencies will remain unchanged in all generations after the first.
The discussion of random mating and the HardyWeinberg law in the previous chapter was premised on the population size being infinite. In finite populations, random changes in allele frequencies result from variation in the number of offspring between individuals and, if the species is diploid and sexual, from Mendel’s law of segregation.
Genetic drift, the name given to these random changes, affects evolution in two important ways. One is as a dispersive force that removes genetic variation from populations. The rate of removal is inversely proportional to the population size, so genetic drift is a very weak dispersive force in most natural populations. The other is drift’s effect on the probability of survival of new mutations, an effect that is important even in the largest of populations. In fact, we will see that the survival probability of beneficial mutations is (approximately) independent of the population size.
Evolution can never be repeated.
Genetic drift is a random process. The outcome of genetic drift cannot be stated with certainty. Rather, either probabilities must be assigned to different outcomes or the average outcome must be described.
The probability of ultimate fixation of a neutral allele is its current frequency.
Genetic drift is an evolutionary force that changes both allele and genotype frequencies. No population can escape its influence. Yet it is a very weak evolutionary force in large populations, prompting a great deal of debate over its relative importance in evolution. Drift is undeniably important for the dynamics of rare alleles, in small subdivided populations with very low migration rates, and in the neutral theory of molecular evolution. Beyond these three arenas, there is little agreement about the importance of drift.
Genetic drift appears to call into question the validity, or at least the utility, of the HardyWeinberg law. However, this is not the case except in the smallest of populations. The attainmentof HardyWeinberg frequencies takes only a generation or two. Viewed as anevolutionary force, random mating has a timescale of one or twogenerations. Drift has a time scale of 2N generations, vastly larger than one or two for natural populations. When two forces have such different time scales, they rarely interact in an interesting way. This is certainly true for the interaction of drift and random mating. In any particular generation, the population will appear to be in HardyWeinberg equilibrium. The deviation of the frequency of a genotype from the HardyWeinberg expectation will be no more than about 1/(2N), certainly not a measurable deviation. Moreover, the allele frequency will not change by a measurable amount in a single generation.
In most models of natural populations, no matter how complex, the heterozygosity eventually decreases geometrically, just as it does in our idealized population. However, the rate of decrease will no longer be 1/(2N), but will be some new rate, call it 1/(2Ne), that depends on the particulars of the model. The parameter Ne is called the effective size of the population. It is the size of an idealized population whose rate of decay of heterozygosity is the same as that of the complicated population. Thus, we need only investigate how each complicating assumption influences the effective size of the population. From then on, we can simply substitute Ne for N in all of the preceding equations.
The harmonic mean of a sequence of numbers is always less than or equal to the arithmetic mean.
回应 20110402 12:58

AEIOU (幸福的奥地利，结婚去吧。)
Chapter 1  The HardyWeinberg Law I feel strongly that a student who understands well the core of population genetics is much better equipped to understand evolution than is one who understands less well each of a greater number of topics. It differs from much of biology in that its important insights are theoretical rather than observational or experimental. The objects of study are primarily...20110402 12:58
Chapter 1  The HardyWeinberg LawI feel strongly that a student who understands well the core of population genetics is much better equipped to understand evolution than is one who understands less well each of a greater number of topics.
It differs from much of biology in that its important insights are theoretical rather than observational or experimental.
The objects of study are primarily the frequencies and fitnesses of genotypes in natural populations. Evolution is the change in the frequencies of genotypes through time, perhaps due to their differences in fitness. While genotype frequencies are easily measured, their change is not. The time scale of change of most naturally occurring genetic variants is very long, probably on the order of tens of thousands to millions of years. Changes this slow are impossible to observe directly. Fitness differences between genotypes, which may be responsible for some of the frequency changes, are so extraordinarily small, probably less than 0.01 percent, that they too are impossible to measure directly. Although we can observe the state of a population, there really is no way to explore directly the evolution of a population.
Years ago, Ernst Mayr mocked this approach as “bean bag genetics”. In so doing, he echoed a view held by many of the pioneers of our field that natural selection acts on highly interactive coadapted genomes whose evolution cannot be understood by considering the evolution of a few loci in isolation from all others. Although genomes are certainly coadapted, there is precious little evidence that there are strong interactions between most polymorphic alleles in natural populations. The modern view, spurred on by the rush of DNA sequence data, is that we can profitably study loci in isolation.
The HardyWeinberg law describes the equilibrium state of a single locus in a randomly mating diploid population that is free of other evolutionary forces, such as mutation, migration, and genetic drift.
The autosomal loci of hermaphrodites reach their HardyWeinberg equilibrium in a single generation of random mating, no matter how far the initial genotype frequencies are from their equilibrium values.
Chapter 2  Genetic DriftThe frequencies of the alleles do not change M a result of random mating. Random mating can change genotype frequencies, not allele frequencies. Consequently, the HardyWeinberg genotype frequencies will remain unchanged in all generations after the first.
The discussion of random mating and the HardyWeinberg law in the previous chapter was premised on the population size being infinite. In finite populations, random changes in allele frequencies result from variation in the number of offspring between individuals and, if the species is diploid and sexual, from Mendel’s law of segregation.
Genetic drift, the name given to these random changes, affects evolution in two important ways. One is as a dispersive force that removes genetic variation from populations. The rate of removal is inversely proportional to the population size, so genetic drift is a very weak dispersive force in most natural populations. The other is drift’s effect on the probability of survival of new mutations, an effect that is important even in the largest of populations. In fact, we will see that the survival probability of beneficial mutations is (approximately) independent of the population size.
Evolution can never be repeated.
Genetic drift is a random process. The outcome of genetic drift cannot be stated with certainty. Rather, either probabilities must be assigned to different outcomes or the average outcome must be described.
The probability of ultimate fixation of a neutral allele is its current frequency.
Genetic drift is an evolutionary force that changes both allele and genotype frequencies. No population can escape its influence. Yet it is a very weak evolutionary force in large populations, prompting a great deal of debate over its relative importance in evolution. Drift is undeniably important for the dynamics of rare alleles, in small subdivided populations with very low migration rates, and in the neutral theory of molecular evolution. Beyond these three arenas, there is little agreement about the importance of drift.
Genetic drift appears to call into question the validity, or at least the utility, of the HardyWeinberg law. However, this is not the case except in the smallest of populations. The attainmentof HardyWeinberg frequencies takes only a generation or two. Viewed as anevolutionary force, random mating has a timescale of one or twogenerations. Drift has a time scale of 2N generations, vastly larger than one or two for natural populations. When two forces have such different time scales, they rarely interact in an interesting way. This is certainly true for the interaction of drift and random mating. In any particular generation, the population will appear to be in HardyWeinberg equilibrium. The deviation of the frequency of a genotype from the HardyWeinberg expectation will be no more than about 1/(2N), certainly not a measurable deviation. Moreover, the allele frequency will not change by a measurable amount in a single generation.
In most models of natural populations, no matter how complex, the heterozygosity eventually decreases geometrically, just as it does in our idealized population. However, the rate of decrease will no longer be 1/(2N), but will be some new rate, call it 1/(2Ne), that depends on the particulars of the model. The parameter Ne is called the effective size of the population. It is the size of an idealized population whose rate of decay of heterozygosity is the same as that of the complicated population. Thus, we need only investigate how each complicating assumption influences the effective size of the population. From then on, we can simply substitute Ne for N in all of the preceding equations.
The harmonic mean of a sequence of numbers is always less than or equal to the arithmetic mean.
回应 20110402 12:58

AEIOU (幸福的奥地利，结婚去吧。)
Chapter 1  The HardyWeinberg Law I feel strongly that a student who understands well the core of population genetics is much better equipped to understand evolution than is one who understands less well each of a greater number of topics. It differs from much of biology in that its important insights are theoretical rather than observational or experimental. The objects of study are primarily...20110402 12:58
Chapter 1  The HardyWeinberg LawI feel strongly that a student who understands well the core of population genetics is much better equipped to understand evolution than is one who understands less well each of a greater number of topics.
It differs from much of biology in that its important insights are theoretical rather than observational or experimental.
The objects of study are primarily the frequencies and fitnesses of genotypes in natural populations. Evolution is the change in the frequencies of genotypes through time, perhaps due to their differences in fitness. While genotype frequencies are easily measured, their change is not. The time scale of change of most naturally occurring genetic variants is very long, probably on the order of tens of thousands to millions of years. Changes this slow are impossible to observe directly. Fitness differences between genotypes, which may be responsible for some of the frequency changes, are so extraordinarily small, probably less than 0.01 percent, that they too are impossible to measure directly. Although we can observe the state of a population, there really is no way to explore directly the evolution of a population.
Years ago, Ernst Mayr mocked this approach as “bean bag genetics”. In so doing, he echoed a view held by many of the pioneers of our field that natural selection acts on highly interactive coadapted genomes whose evolution cannot be understood by considering the evolution of a few loci in isolation from all others. Although genomes are certainly coadapted, there is precious little evidence that there are strong interactions between most polymorphic alleles in natural populations. The modern view, spurred on by the rush of DNA sequence data, is that we can profitably study loci in isolation.
The HardyWeinberg law describes the equilibrium state of a single locus in a randomly mating diploid population that is free of other evolutionary forces, such as mutation, migration, and genetic drift.
The autosomal loci of hermaphrodites reach their HardyWeinberg equilibrium in a single generation of random mating, no matter how far the initial genotype frequencies are from their equilibrium values.
Chapter 2  Genetic DriftThe frequencies of the alleles do not change M a result of random mating. Random mating can change genotype frequencies, not allele frequencies. Consequently, the HardyWeinberg genotype frequencies will remain unchanged in all generations after the first.
The discussion of random mating and the HardyWeinberg law in the previous chapter was premised on the population size being infinite. In finite populations, random changes in allele frequencies result from variation in the number of offspring between individuals and, if the species is diploid and sexual, from Mendel’s law of segregation.
Genetic drift, the name given to these random changes, affects evolution in two important ways. One is as a dispersive force that removes genetic variation from populations. The rate of removal is inversely proportional to the population size, so genetic drift is a very weak dispersive force in most natural populations. The other is drift’s effect on the probability of survival of new mutations, an effect that is important even in the largest of populations. In fact, we will see that the survival probability of beneficial mutations is (approximately) independent of the population size.
Evolution can never be repeated.
Genetic drift is a random process. The outcome of genetic drift cannot be stated with certainty. Rather, either probabilities must be assigned to different outcomes or the average outcome must be described.
The probability of ultimate fixation of a neutral allele is its current frequency.
Genetic drift is an evolutionary force that changes both allele and genotype frequencies. No population can escape its influence. Yet it is a very weak evolutionary force in large populations, prompting a great deal of debate over its relative importance in evolution. Drift is undeniably important for the dynamics of rare alleles, in small subdivided populations with very low migration rates, and in the neutral theory of molecular evolution. Beyond these three arenas, there is little agreement about the importance of drift.
Genetic drift appears to call into question the validity, or at least the utility, of the HardyWeinberg law. However, this is not the case except in the smallest of populations. The attainmentof HardyWeinberg frequencies takes only a generation or two. Viewed as anevolutionary force, random mating has a timescale of one or twogenerations. Drift has a time scale of 2N generations, vastly larger than one or two for natural populations. When two forces have such different time scales, they rarely interact in an interesting way. This is certainly true for the interaction of drift and random mating. In any particular generation, the population will appear to be in HardyWeinberg equilibrium. The deviation of the frequency of a genotype from the HardyWeinberg expectation will be no more than about 1/(2N), certainly not a measurable deviation. Moreover, the allele frequency will not change by a measurable amount in a single generation.
In most models of natural populations, no matter how complex, the heterozygosity eventually decreases geometrically, just as it does in our idealized population. However, the rate of decrease will no longer be 1/(2N), but will be some new rate, call it 1/(2Ne), that depends on the particulars of the model. The parameter Ne is called the effective size of the population. It is the size of an idealized population whose rate of decay of heterozygosity is the same as that of the complicated population. Thus, we need only investigate how each complicating assumption influences the effective size of the population. From then on, we can simply substitute Ne for N in all of the preceding equations.
The harmonic mean of a sequence of numbers is always less than or equal to the arithmetic mean.
回应 20110402 12:58
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订阅关于Population Genetics的评论:
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0 有用 invoker 20151223
这本比那principles of population Genetics好读多了。
0 有用 [已注销] 20100102
2010.01  CPY 
0 有用 Pecari tajacu 20100724
还有很多要看
0 有用 乌拉 20130225
很有纪念感的小册子, 那么就作为我的纪念吧.
0 有用 invoker 20151223
这本比那principles of population Genetics好读多了。
0 有用 乌拉 20130225
很有纪念感的小册子, 那么就作为我的纪念吧.
0 有用 Pecari tajacu 20100724
还有很多要看
0 有用 [已注销] 20100102
2010.01  CPY 