作者:
David A. Sinclair, Matthew D. LaPlante 出版社: Atria Books 副标题: Why We Age—and Why We Don't Have To 出版年: 2019-9-10 页数: 432 定价: USD 14.99 装帧: 平装 ISBN: 9781501191978
From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at th...
From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes—the kind that inevitably happens as we get older—makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if aging is a disease—and that disease is treatable? In Lifespan, one of the world’s foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn’t immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab—that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes—the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, and exercising with the right intensity—that have been shown to help lead to longer lives. Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young.
作者简介
· · · · · ·
David Sinclair, PhD, AO is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top 50 most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than 35 awards for his research...
David Sinclair, PhD, AO is a professor of genetics at Harvard Medical School. One of the leading innovators of his generation, he has been named by Time as “one of the 100 most influential people in the world” and top 50 most influential people in healthcare. He is a board member of the American Federation for Aging Research and has received more than 35 awards for his research and major scientific breakthroughs. Dr. Sinclair and his work have been featured on 60 Minutes, Today, The Wall Street Journal, The New York Times, Fortune, and Newsweek, among others. He lives in Boston and enjoys hiking and kayaking with his wife and three children. To learn more, visit LifespanBook.com and follow him on Twitter @DavidASinclair.
Matthew LaPlante is an associate professor of journalistic writing at Utah State University, where he teaches news reporting and feature writing. A former US Navy intelligence specialist and Middle East war correspondent, he is the author of Superlative: The Biology of Extremes and the cowriter of multiple other books on the intersection of science and society. He lives in Salt Lake City and skis in Big Cottonwood Canyon. To learn more, visit MDLaPlante.com and follow him on Twitter @MDLaPlante.
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目录
· · · · · ·
Introduction: A Grandmother’s Prayer
PART I: WHAT WE KNOW (THE PAST)
1. Viva Primordium
2. The Demented Pianist
3. The Blind Epidemic
PART II: WHAT WE’RE LEARNING (THE PRESENT)
· · · · · ·
(更多)
Introduction: A Grandmother’s Prayer
PART I: WHAT WE KNOW (THE PAST)
1. Viva Primordium
2. The Demented Pianist
3. The Blind Epidemic
PART II: WHAT WE’RE LEARNING (THE PRESENT)
4. Longevity Now
5. A Better Pill to Swallow
6. Big Steps Ahead
7. The Age of Innovation
PART III: WHERE WE’RE GOING (THE FUTURE)
8. The Shape of Things to Come
9. A Path Forward
Conclusion
Acknowledgement
Notes
Sinclair Disclosure
The Scale of Things
Cast of Characters
Glossary
Index
· · · · · · (收起)
原文摘录
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At the nanoscale, it is merely an ordered set of chemical reactions, concentrating and assembling atoms that would normally never assemble, or breaking apart molecules that would normally never disintegrate. Life does this using proteinaceous Pac-Men called enzymes made up of coils and layered mats of amino acid chains.
Enzymes make life possible by taking advantage of fortuitous molecular movements. Every second you are alive, thousands of glucose molecules are captured within each of your trillion of cells by an enzyme called glucokinase, which fuse glucose molecules to phosphorus atoms, tagging them for energy production. Most of the energy created is used by a multicomponent RNA and protein complex called a ribosome, whose primary job is to capture amino acids and fuse them with other... (查看原文)
Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death
Looks like David wrote the book in a rush. It's supposed to be a book describing the theory of aging, but he spent a lot of efforts explaining how modern healthcare is changing..
pluskid
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1 有用 optman 2023-09-27 15:58:24 广西
看了前几章，后面的看不下去了，就像很多人评价的那样，太罗嗦，主题太乱。但是我大概get到了作者的意思，衰老是因为信息丢失，不是genome而是epigenome，后者决定了每个细胞的形态。人体的基因要经常修复，才不至于发展到不可收拾的地步，而修复是需要能量的，这有涉及到线粒体。而线粒体工作需要的原材料是什么，那就是NAD，那么NAD的前驱物是什么？对，就是NMN和NR。还有NADH是NAD的还原形... 看了前几章，后面的看不下去了，就像很多人评价的那样，太罗嗦，主题太乱。但是我大概get到了作者的意思，衰老是因为信息丢失，不是genome而是epigenome，后者决定了每个细胞的形态。人体的基因要经常修复，才不至于发展到不可收拾的地步，而修复是需要能量的，这有涉及到线粒体。而线粒体工作需要的原材料是什么，那就是NAD，那么NAD的前驱物是什么？对，就是NMN和NR。还有NADH是NAD的还原形态，可以重新变回NAD。这就是你在保健品市场上看到的各种名词！通过这些补充这些前驱物和还原态，可以恢复人体中日渐消耗的NAD，从而恢复线粒体活力，恢复基因修复能力，从而永葆青春！大概搜了一下，发现NMN真的是有神效，不是智商税，就是价格太贵！ (展开)
0 有用 MX 2024-02-03 23:56:23 日本
Can we stop allowing sloppy writing to be published thx.
1 有用 深情的艾老师 2022-11-04 00:29:37 挪威
Youth → broken DNA → genome instability → disruption of DNA packaging and gene regulation (the epigenome) → loss of cell identity → cellular senescence → disease → death
3 有用 zhifeige 2020-01-31 03:08:11
Looks like David wrote the book in a rush. It's supposed to be a book describing the theory of aging, but he spent a lot of efforts explaining how modern healthcare is changing..
0 有用 竹去 2021-12-31 17:47:34
so optimistic that it borders on the verge of pseudo science...(prove me wrong, please)
0 有用 MX 2024-02-03 23:56:23 日本
Can we stop allowing sloppy writing to be published thx.
0 有用 入江直树 2023-12-31 12:02:32 江苏
有些有价值的内容。但作者太过热衷提及自己身处的那个学术泡泡，不知道这对于读者来说一点意思也没有。后面1/3重复了很多Enlightenment Now里面的观点。这书100页就好了。
0 有用 WOO 2023-11-01 08:02:14 上海
激活人类原始的生存回路 ，少吃 保持饥饿 ，5/2 IF，每天 10 分钟HIIT ，寒冷 chill
1 有用 optman 2023-09-27 15:58:24 广西
看了前几章，后面的看不下去了，就像很多人评价的那样，太罗嗦，主题太乱。但是我大概get到了作者的意思，衰老是因为信息丢失，不是genome而是epigenome，后者决定了每个细胞的形态。人体的基因要经常修复，才不至于发展到不可收拾的地步，而修复是需要能量的，这有涉及到线粒体。而线粒体工作需要的原材料是什么，那就是NAD，那么NAD的前驱物是什么？对，就是NMN和NR。还有NADH是NAD的还原形... 看了前几章，后面的看不下去了，就像很多人评价的那样，太罗嗦，主题太乱。但是我大概get到了作者的意思，衰老是因为信息丢失，不是genome而是epigenome，后者决定了每个细胞的形态。人体的基因要经常修复，才不至于发展到不可收拾的地步，而修复是需要能量的，这有涉及到线粒体。而线粒体工作需要的原材料是什么，那就是NAD，那么NAD的前驱物是什么？对，就是NMN和NR。还有NADH是NAD的还原形态，可以重新变回NAD。这就是你在保健品市场上看到的各种名词！通过这些补充这些前驱物和还原态，可以恢复人体中日渐消耗的NAD，从而恢复线粒体活力，恢复基因修复能力，从而永葆青春！大概搜了一下，发现NMN真的是有神效，不是智商税，就是价格太贵！ (展开)
0 有用 源 2023-05-14 15:50:48 广东
近年来对我最有价值的一本书，传递的科研无价，作者功德无量！